Senior Principal Scientist, Oncology Translational Research – Prostate

Johnson & Johnson

. Lead integrated translational research and biomarker strategies for prostate cancer drug development programs .

Posted 11/3/2026full-timeUnited StatesSenior💰 $140,000 - $241,500 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in designing and implementing biomarker strategies for prostate cancer drug development, integrating clinical and molecular data into actionable insights while collaborating effectively across cross-functional teams.

Highest-signal resume keywords

PhD In Biomedical SciencesBiopharmaceutical Drug Development ExperienceTranslational Oncology ExpertiseBiomarker Strategy DesignExperience With Circulating Biomarkers

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Applicant Tracking System Keywords

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Hard Skills

Biomarker AnalysisClinical Trial Protocol DesignIn Vitro Experiment ManagementStatistical Analysis FrameworksBiomarker Sample Collection StrategiesTranslational ResearchImmunology ExpertiseTumor Microenvironment BiologyPrecision OncologyExperience With PROTACs

Soft Skills

Scientific CommunicationProject ManagementOrganizational SkillsPresentation SkillsCollaboration

Tools & Technologies

Digital PathologyComputational ApproachesTissue-Based BiomarkersSpatial BiologyCirculating Tumor DNA (ctDNA)Circulating Tumor Cells (CTCs)

Industry Keywords

Translational ResearchBiomarker ScienceProstate Cancer BiologyTherapeutic DevelopmentRegistrational Clinical Trials

About the role

Key responsibilities & impact

Lead integrated translational research and biomarker strategies for prostate cancer drug development programs
Design biomarker plans aligned with mechanism of action and clinical development objectives, including pharmacodynamic, target engagement, response, safety, and resistance biomarkers
Guide biomarker selection and prioritization across genomics, transcriptomics, circulating biomarkers, tissue-based molecular and spatial biomarkers, immunologic and tumor microenvironment profiling, digital pathology, and computational approaches
Design and manage in vitro experiments to identify combination strategies and response/resistance patterns
Integrate biomarker hypotheses into clinical trial protocols, biomarker analysis plans, and statistical analysis frameworks
Design biomarker sample collection and analysis strategies for Phase I–III clinical trials
Ensure biomarker analyses support development-program decision points
Collaborate with clinical operations and laboratory partners on biomarker implementation
Represent Translational Research in cross-functional governance discussions and program meetings
Coordinate biomarker activities across internal laboratories, CRO partners, and external collaborators
Ensure biomarker assays are fit-for-purpose and analytically robust for clinical trial use
Support biomarker strategy documentation for regulatory interactions and submissions
Evaluate and prioritize external translational research proposals and collaborations
Partner with academic investigators and technology providers on biomarker discovery and validation
Identify emerging technologies relevant to prostate cancer translational biology
Integrate clinical outcomes, genomic and molecular data, pathology, tissue-based biomarkers, and circulating biomarker data into actionable insights
Prepare and present findings to governance committees and cross-functional teams
Represent the company at scientific conferences
Contribute to peer-reviewed publications and scientific presentations

Requirements

What you’ll need

PhD in biomedical sciences (e.g., pharmacology, immunology, cancer biology, molecular biology, or related discipline)
Postdoctoral training in a relevant biomedical field
Minimum 3 years of biopharmaceutical drug development experience after postdoc
Experience designing and implementing biomarker strategies in clinical trials
Strong background in translational oncology and biomarker science
Demonstrated ability to operate effectively in matrixed cross-functional teams
Excellent scientific communication, writing, and presentation skills
Strong organizational and project management capabilities
Experience in prostate cancer biology and therapeutic development
Experience with PROTACs, RIPTACs, and other novel cell-modulating therapies
Expertise in immunology, tumor microenvironment biology, or precision oncology
Experience with circulating biomarkers such as ctDNA or CTCs
Familiarity with tissue-based biomarkers, spatial biology, or digital pathology
Experience supporting registrational clinical trials

Benefits

Comp & perks

Medical, dental, and vision insurance
Life insurance
Short- and long-term disability insurance
Business accident insurance
Group legal insurance
Consolidated retirement plan (pension)
401(k) savings plan
Long-term incentive program
Vacation – 120 hours per calendar year
Sick time – 40 hours per calendar year; 56 hours for employees residing in Washington State
Holiday pay, including floating holidays – 13 days per calendar year
Work, Personal and Family Time – up to 40 hours per calendar year
Parental Leave – 480 hours within one year of birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year