Senior Scientist, In Silico Discovery

Johnson & Johnson

. Develop components for automated structure-based modeling workflows, including ligand preparation, protein preparation, docking, docking selection, and free energy calculations .

Posted 9/24/2026full-timeBeerse • BelgiumSenior💰 €75,500 - €117,300 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in developing automated workflows for structure-based computational drug discovery, leveraging strong programming skills in Python and knowledge of software engineering best practices. Collaborates effectively across multidisciplinary teams to align scientific workflows with platform strategies and operational standards.

Highest-signal resume keywords

PhD In Computational ScienceStrong Programming Skills In PythonExperience Developing Automated WorkflowsKnowledge Of Structure-Based Computational Drug DiscoveryFamiliarity With Workflow Orchestration Frameworks

ATS Keywords

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Hard Skills

Automated Workflow DevelopmentPipeline DevelopmentSoftware Engineering Best PracticesVersion ControlTestingContinuous Integration And Delivery (CI/CD)Free Energy MethodsVirtual ScreeningCo-FoldingAgentic AI

Soft Skills

Strong Problem-Solving SkillsCreative Solution Development

Tools & Technologies

RDKitModern AI/ML LibrariesOpen-Source Resources

Industry Keywords

Computational ChemistryIn Silico DiscoveryCADDDrug Discovery Data SciencesCheminformaticsIn Silico Biologics

Tech Stack

Tools & technologies

Python

About the role

Key responsibilities & impact

Develop components for automated structure-based modeling workflows, including ligand preparation, protein preparation, docking, docking selection, and free energy calculations
Advance workflow components from prototypes to deployable solutions
Expand existing automated components and develop automation for new structure-based tools
Collaborate with platform and automation teams to implement scientific workflows using common architectures, reusable services, and enterprise standards
Contribute requirements, user feedback, and future workflow needs to evolve the workflow platform and automated DMTA environment
Ensure scientific workflows align with platform strategy, technical standards, security requirements, and operational best practices
Explore and develop co-folding across computational workflows, including future automation efforts
Leverage agentic AI to support programming, accelerate development, and expand AI-enabled workflows
Collaborate across In Silico Discovery with global CADD, Drug Discovery Data Sciences, Cheminformatics, and In Silico Biologics teams

Requirements

What you’ll need

PhD in computational science, computational chemistry, or a related field
Knowledge of structure-based computational drug discovery
Strong programming skills, preferably in Python
Experience developing automated workflows, pipelines, or scientific applications
Familiarity with workflow orchestration frameworks
Knowledge of software engineering best practices, including version control, testing, and continuous integration and delivery (CI/CD)
Strong problem-solving skills and ability to develop creative, innovative solutions meeting project objectives
Ability to travel domestically and internationally up to 10% of the time
Preferred: Experience with open-source resources, libraries, and toolkits such as RDKit
Preferred: Experience with modern AI/ML libraries and platforms
Preferred: Experience using agentic AI to support programming and software development
Preferred: Experience in free energy methods, virtual screening, or co-folding
Postdoctoral research in computational chemistry, industry experience, or other exposure to drug discovery would be beneficial

Benefits

Comp & perks

Annual bonus with set target depending on pay grade/location, based on employee and company performance
Vacation days
Parental leave for a minimum of 12 weeks
Bereavement leave
Caregiver leave
Volunteer leave
Well-being reimbursement
Financial, physical, and mental health programs
Service anniversary and recognition awards
Insurance plans for employees and eligible dependents in some locations