Associate Director – Director of Product Management, Signatera Hematologic Oncology

Natera

. Own the Signatera product strategy and roadmap for hematologic malignancies, beginning with multiple myeloma and lymphomas .

Posted 11/3/2026full-timeRemote • United StatesSenior💰 $180,300 - $230,900 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in product management and market analytics within the diagnostics and biotech sectors, with a strong focus on oncology molecular testing and regulatory environments. Proficient in translating clinical needs into actionable product strategies while leveraging data analysis and financial modeling to drive product performance and market entry.

Highest-signal resume keywords

Product ManagementOncology Molecular TestingNext-Generation Sequencing (NGS)Clinical Trials ExperienceRegulatory Compliance

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Data AnalysisClinical ValidationFinancial ModelingGenomic Data AnalysisBiomarkersLaboratory Developed Test (LDT)Market AnalyticsProduct Requirements DefinitionMetrics DevelopmentVoice of Customer Interviews

Soft Skills

Strong Analytical SkillsRelationship-BuildingStrong Written and Oral CommunicationOrganization and Time ManagementAbility to Lead Without Authority

Tools & Technologies

MS ExcelMS WordMS PowerPoint

Industry Keywords

Hematologic MalignanciesMultiple MyelomaLymphomasIVD Regulated EnvironmentsMRD TrackingClinical Evidence GenerationPayer CoverageAdvisory BoardsCongress PresentationsLaboratory Requirements

About the role

Key responsibilities & impact

Own the Signatera product strategy and roadmap for hematologic malignancies, beginning with multiple myeloma and lymphomas
Develop and execute the heme product roadmap
Lead market entry planning as a laboratory developed test (LDT), including clinical validation, CLIA and state requirements, reimbursement, payer considerations, and launch readiness
Define product requirements for blood-based malignancies with R&D, Lab Operations, and Software Engineering
Lead product support for clinical trials using Signatera in hematologic oncology, including IUO studies and the path toward IVD and regulated use
Partner with Regulatory, Clinical, and Business Development on trial start-up, study requirements, and companion diagnostic opportunities
Build product performance metrics and dashboards; analyze test volume, adoption, ordering patterns, turnaround time, and retention
Partner with Medical Affairs and Clinical on evidence generation, study design, investigators, trial partners, publications, and congress presentations
Guide development of Signatera Genome in heme, including whole genome sequencing, phased variants, and structural variants
Conduct Voice of Customer interviews, market research, and competitive intelligence
Engage key opinion leaders, advisory boards, and congresses including ASH, EHA, and ASCO
Work with Marketing on positioning, launch plans, pricing, and collateral
Build business cases and financial models
Present strategy, progress, and data-driven recommendations to executive leadership
Perform other duties as assigned

Requirements

What you’ll need

Bachelor’s degree in life sciences, statistics, engineering, or a related field
5+ years of experience in product management, product marketing, or market analytics at a diagnostics, biotech, or pharmaceutical company
Working knowledge of oncology molecular testing, next-generation sequencing (NGS), biomarkers, NGS bioinformatic workflows, and genomic data analysis
Experience with data analysis
Experience with clinical trials
Experience in IUO and IVD regulated environments required
Experience bringing a molecular test to market as an LDT, including clinical validation and laboratory requirements
Experience designing or supporting clinical evidence generation
30–40% travel for advisory boards, congresses, and customer meetings
Understanding of MRD in multiple myeloma and lymphomas
Understanding of somatic variants in whole genome sequencing and MRD tracking
Understanding of LDT market entry requirements and evidence for clinical adoption and payer coverage
Ability to translate customer and clinical needs into product requirements
Strong analytical skills and ability to build metrics, interpret data, and present findings
Basic financial modeling skills
Proficiency with MS Excel, Word, and PowerPoint
Ability to lead without authority and influence cross-functional teams
Strong written and oral communication skills
Ability to explain complex topics simply
Strong customer focus and relationship-building with thought leaders
Strong organization and time management; ability to manage multiple projects and deadlines
Availability during Pacific time hours required
Site-based presence in San Carlos, CA, Boulder, CO, or Austin, TX preferred

Benefits

Comp & perks

Comprehensive medical, dental, vision, life and disability plans for eligible employees and dependents
Free testing for employees and immediate families
Fertility care benefits
Pregnancy and baby bonding leave
401(k) benefits
Commuter benefits
Employee referral program
Flexible remote home office / hybrid office setting
Global, diverse and inclusive workplace