Nautilus Biotechnology

Scientist

• Partner with scientists to deliver proteoform and proteome assays built on Nautilus's single-molecule proteomics platform powered by Iterative Mapping
• Independently analyze Iterative Mapping data end to end, from run metadata through image processing, protein decoding, and statistical conclusions
• Communicate results and recommendations clearly and actionably to members of the company regardless of scientific background
• Optimize assay performance by establishing levers for improving reproducibility and quantitative accuracy
• Guide experimental design, including controls, replicates, and sample sizes
• Conduct sensitivity and power analyses that set acceptance criteria before data is collected
• Diagnose unexpected experimental results by forming and testing hypotheses spanning reagents, instruments, image processing, and algorithms
• Feed lessons learned into subsequent assay design
• Develop and maintain quality control metrics and reports used to evaluate experimental runs
• Set defensible thresholds and explain the meaning and importance of each metric
• Access and integrate data from cloud data warehouses, object storage, on-premises file servers, and experiment metadata records
• Reconcile data inconsistencies as needed
• Convert recurring analyses into reusable, tested software tools
• Work cross-functionally with chemists, engineers, and algorithm developers on company-wide project teams
• Report to a Bioinformatics Fellow

Senior Bioinformatics Scientist