Clinical Pharmacology Lead – Manager

Pfizer

. Support Pfizer’s Internal Medicine clinical pharmacology portfolio .

Posted 9/23/2026full-timeUnited StatesSenior💰 $106,000 - $176,600 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in clinical pharmacology, including mechanistic PK/PD modeling and clinical trial simulations, while effectively collaborating with multifunctional teams to deliver impactful project outcomes. Proficient in regulatory documentation and innovative analytical methods to optimize clinical development plans.

Highest-signal resume keywords

Mechanistic PK/PD ModelingClinical Trial SimulationsRegulatory DocumentationClinical Pharmacology ExpertiseQuantitative Skills

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

PharmacokineticsPharmacometricsNONMEMRClinical Development PlansDose-Range Finding StrategiesMIDD PlansProtocol AuthoringPK/PD AnalysesInnovative Analytical Methods

Soft Skills

Excellent Written CommunicationExcellent Verbal CommunicationPresentation SkillsCollaborationInfluencing Skills

Certifications & Qualifications

M.D.Ph.D.Pharm D.

Industry Keywords

Clinical PharmacologyInternal MedicineRegulatory GuidelinesSOPsGlobal Team MeetingsIndustry ConsortiaPublicationsScientific Societies

About the role

Key responsibilities & impact

Support Pfizer’s Internal Medicine clinical pharmacology portfolio
Act as Clinical Pharmacology representative on Clinical Sub Teams, Development Teams, and other multifunctional teams
Provide clinical pharmacology expertise, leadership, and deliverables for assigned projects
Design and execute clinical pharmacology plans and implement best practices
Collaborate with other disciplines on preclinical PK/PD knowledge, safe human administration, and predictive models before FIH
Plan and oversee project-level clinical pharmacology activities, including clinical development plans and PK/PD analyses
Plan and oversee study-level activities, including protocol authoring, clinical phase oversight, and reporting
Ensure appropriate dose-range finding strategies and optimal doses and dosage regimens
Design and implement end-to-end MIDD plans
Use innovative analytical methods to optimize doses, dosage regimens, and study designs
Contribute to regulatory documents including briefing documents, regulatory queries, investigator’s brochures, IND, NDA/MAA
Stay current with literature, regulatory guidelines, internal guidance, and SOPs
Influence the external environment through publications, presentations, scientific societies, and industry consortia

Requirements

What you’ll need

Strong quantitative skills and expertise in mechanistic PK/PD modeling/systems pharmacology, literature meta-analyses, population modeling, and clinical trial simulations using NONMEM, R, etc.
M.D./Ph.D., or equivalent training/experience in pharmacokinetics, pharmacometrics, clinical pharmacology, engineering, or related discipline, with 0+ years of industry experience
Pharm D. or equivalent training/experience in pharmacokinetics, pharmacometrics, clinical pharmacology, engineering, or related discipline, with 2+ years of industry experience
Excellent written and verbal communication skills
Demonstrated presentation skills
Ability to work in global team meetings across different time zones periodically based on business necessity
Ability to influence and collaborate with peers to achieve meaningful outcomes and create business impact
Candidates must be authorized to be employed in the U.S. by any employer
Permanent work authorization in the United States is required
U.S. work visa sponsorship is not available now or in the future

Benefits

Comp & perks

Global Performance Plan with a bonus target of 15.0% of base salary
Share based long term incentive program
401(k) plan with Pfizer Matching Contributions
Additional Pfizer Retirement Savings Contribution
Paid vacation, holiday and personal days
Paid caregiver/parental and medical leave
Medical, prescription drug, dental and vision coverage
Relocation assistance may be available based on business needs and/or eligibility