Executive Director, Translational & Computational Biology

Pfizer

. Lead a portfolio of high-value biological, translational, and clinical questions across R&D .

Posted 11/10/2026full-timeUnited StatesLead💰 $230,900 - $384,800 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in leading cross-functional scientific programs, translating complex biological and clinical data into actionable insights, and applying computational methods to drive evidence-based decisions in biomedical research. Proficient in multi-omics, AI strategies, and statistical reasoning to influence scientific and development outcomes.

Highest-signal resume keywords

PhD, MD, PharmD, Or Equivalent Advanced DegreeExperience Leading Cross-Functional Scientific ProgramsWorking Proficiency In R And/or PythonMachine Learning And AI Concepts Relevant To Biomedical ResearchBiological And Clinical Data Analysis And Visualization

ATS Keywords

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Hard Skills

Computational BiologyTranslational BiologyBioinformaticsGeneticsGenomicsBiostatisticsStatistical ReasoningExperimental DesignQuantitative InterpretationReproducible Research

Soft Skills

Influencing Senior StakeholdersClear Scientific ReasoningMentoring And Guiding ScientistsCommunication Of Complex EvidenceCollaboration Across R&D Functions

Tools & Technologies

AI-Enabled Scientific WorkflowsComputational MethodsData Visualization ToolsStatistical SoftwareMulti-Omics Platforms

Industry Keywords

Translational MedicineClinical DevelopmentPrecision MedicineBiomarker ScienceReal-World Data And Evidence

Tech Stack

Tools & technologies

Python

About the role

Key responsibilities & impact

Lead a portfolio of high-value biological, translational, and clinical questions across R&D
Serve as a senior scientific bridge between therapeutic-area teams and the AI Core
Shape analytical and AI strategies, including study design, validation, and evidence standards
Interpret complex multimodal evidence and translate it into clear scientific recommendations
Influence scientific, development, and portfolio decisions through data and biological judgment
Drive adoption and reuse of successful AI-enabled scientific approaches across programs and teams
Identify and prioritize questions where integrated biological, clinical, and computational evidence can materially change decisions
Lead scientific strategy from problem formulation through analysis, validation, interpretation, and recommendation
Generate and test hypotheses connecting molecular mechanisms to patient biology, treatment response, and development strategy
Partner with AI scientists, engineers, computational biologists, statisticians, and domain experts to define fit-for-purpose approaches
Define cohorts, endpoints, labels, biological annotations, evaluation criteria, and validation plans
Guide selection and application of computational methods and AI capabilities
Challenge outputs for biological plausibility, robustness, generalizability, uncertainty, and decision relevance
Advise scientific and clinical leaders across discovery, translational medicine, and clinical development
Build partnerships across R&D functions and represent translational and computational perspectives in cross-functional discussions
Lead or guide analyses involving multi-omics, single-cell and spatial biology, genetics and genomics, perturbational and functional biology, imaging and digital pathology, clinical trial datasets, real-world data and evidence, scientific literature, and multimodal data sources
Establish standards for rigor, reproducibility, validation, and evidence
Assess uncertainty, confounding, bias, alternative explanations, and failure modes
Communicate complex evidence to scientific, clinical, technical, and senior leadership audiences
Mentor and guide scientists and cross-functional colleagues and embed successful approaches into repeatable scientific practice

Requirements

What you’ll need

PhD, MD, PharmD, or equivalent advanced degree in Computational Biology, Translational Biology, Bioinformatics, Genetics, Genomics, Systems Biology, Biomedical Sciences, Biostatistics, or a related discipline with 10+ years of relevant industry or research experience; or a Master's degree with 12+ years of relevant experience, or an equivalent record of scientific and translational impact
Sustained record of translating complex biological and clinical data into insights that influenced meaningful scientific, development, or portfolio decisions
Experience leading cross-functional scientific or translational programs from an ambiguous question to an evidence-based decision
Experience defining strategy and priorities for complex analytical, biomarker, precision-medicine, or data-driven work
Experience applying computational and quantitative approaches to real-world biological and clinical questions
Experience influencing senior stakeholders through clear scientific reasoning, evidence, and recommendations
Experience operating with substantial autonomy in matrixed organizations and aligning contributors without formal authority
Working or strong proficiency in R and/or Python, or equivalent computational tools
Statistical reasoning, experimental design, and quantitative interpretation
Biological and clinical data analysis and visualization
Reproducible research and evidence-generation practices
Machine learning and AI concepts relevant to biomedical research
Ability to evaluate model outputs, uncertainty, limitations, and scientific validity
Demonstrated depth in one or more major scientific domains including multi-omics, single-cell or spatial biology, genetics and genomics, translational or systems biology, imaging or digital pathology, clinical development and biomarker science, or real-world data and evidence
Experience integrating multiple data types and working with AI-enabled scientific workflows is strongly valued
Pfizer requires permanent work authorization in the United States

Benefits

Comp & perks

Pfizer Global Performance Plan with a bonus target of 25.0% of base salary
Share based long term incentive program
401(k) plan with Pfizer Matching Contributions
Additional Pfizer Retirement Savings Contribution
Paid vacation, holiday and personal days
Paid caregiver/parental and medical leave
Medical, prescription drug, dental and vision coverage
Relocation assistance may be available based on business needs and/or eligibility
Senior-level scientific ownership and autonomy
Access to rich biomedical and clinical data and advanced AI capabilities
Direct collaboration with therapeutic-area, clinical, and technical leaders
Opportunity to shape how AI-enabled science is adopted across R&D