Senior Director, Portfolio Strategy, Global Commercial Strategy – Oncology

Pfizer

. Lead development and evolution of the Oncology portfolio strategy across tumor types, mechanisms, modalities, and therapeutic platforms .

Posted 10/13/2026full-timeUnited StatesSenior💰 $214,900 - $358,100 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates extensive experience in Oncology portfolio strategy, integrating scientific and commercial insights to drive investment prioritization and decision-making. Proven ability to lead cross-functional initiatives and influence senior leadership in complex matrix organizations.

Highest-signal resume keywords

Oncology Portfolio StrategyCross-Functional LeadershipStrategic Initiative ManagementFinancial AcumenStakeholder Influence

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Portfolio Strategy DevelopmentRisk EvaluationScenario PlanningMarket Insight GenerationCapital AllocationInvestment PrioritizationLifecycle OptimizationData AnalysisDecision-Support MethodologiesAI-Enabled Tools

Soft Skills

Excellent CommunicationFacilitation SkillsOrganizational SkillsExecutive-Ready StorytellingMentoring

Certifications & Qualifications

Bachelor's Degree

Industry Keywords

PharmaceuticalBiotechnologyLife SciencesCommercial DevelopmentCorporate StrategyStrategy ConsultingPortfolio ManagementEmerging Oncology TrendsComplex Matrix OrganizationsCompliance

About the role

Key responsibilities & impact

Lead development and evolution of the Oncology portfolio strategy across tumor types, mechanisms, modalities, and therapeutic platforms
Develop long-range portfolio scenarios and strategic roadmaps informing investment priorities and portfolio evolution
Assess portfolio strengths, gaps, risks, and opportunities to support decision-making and resource allocation
Drive portfolio-level strategic trade-off discussions balancing scientific opportunity, probability of success, patient impact, and commercial value
Advise Oncology leadership on portfolio prioritization and capital allocation decisions
Develop portfolio recommendations for governance committees and enterprise decision-making forums
Establish frameworks improving consistency, rigor, and transparency in portfolio evaluations
Drive discussions on investment prioritization, development sequencing, indication expansion, and lifecycle optimization
Integrate scientific, clinical, epidemiologic, access, policy, patient, competitive, and commercial insights into portfolio strategies
Monitor emerging oncology trends, standards of care, disruptive technologies, novel modalities, and future treatment paradigms
Lead commercial dashboards, reports, and scenario planning for senior leadership
Partner across Research, Development, Medical, Commercial, Access, Regulatory, Finance, and Business Development
Lead highly visible, cross-functional strategic initiatives with enterprise-wide impact
Shape portfolio management capabilities, methodologies, and AI-enabled decision-support approaches
Mentor and develop colleagues and build team capability
Use AI-enabled tools for landscape synthesis, market insight generation, scenario development, portfolio analysis, and strategy efficiency
Champion responsible, compliant AI-enabled ways of working across oncology strategy and decision-support processes

Requirements

What you’ll need

Bachelor's degree required
12+ years of successful, progressive experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, business development, strategy consulting, corporate strategy, or related fields
Experience in Oncology
Demonstrated experience leading enterprise-level strategic initiatives and influencing significant investment decisions
Experience leading highly visible, cross-functional initiatives in complex matrix organizations
Proven ability to synthesize scientific, clinical, commercial, competitive, and financial information to support portfolio prioritization and capital allocation decisions
Strong strategic, analytical, and financial acumen, including experience evaluating risk, uncertainty, and value creation across multiple opportunities
Track record of influencing senior leadership and driving alignment among diverse stakeholder groups
Excellent communication, facilitation, organizational, and executive-ready storytelling skills
Candidates must be authorized to be employed in the U.S. by any employer
This position requires permanent work authorization in the United States

Benefits

Comp & perks

Global Performance Plan bonus target of 22.5% of base salary
Share based long term incentive program
401(k) plan with Pfizer Matching Contributions
Additional Pfizer Retirement Savings Contribution
Paid vacation, holiday and personal days
Paid caregiver/parental and medical leave
Medical, prescription drug, dental and vision coverage
Relocation assistance may be available based on business needs and/or eligibility