Senior Manager, AI Portfolio – Prioritization Lead

Pfizer

. Own PMO management and portfolio sequencing across the AI Strategy & Realization team .

Posted 10/21/2026full-timeUnited StatesSenior💰 $124,400 - $207,400 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in PMO management and portfolio sequencing, with a strong focus on financial tracking, compliance, and governance standards in AI and analytics. Proven ability to lead project prioritization and value realization efforts within a large, matrixed organization.

Highest-signal resume keywords

PMO ManagementPortfolio ManagementFinancial TrackingValue Realization FrameworksAI Governance Compliance

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Project Intake ProcessFinancial ReportingValue RealizationPrioritization FrameworksAI/Analytics GovernanceCompliance StandardsRisk ManagementCapacity ManagementData AnalyticsOrganizational Skills

Soft Skills

Analytical SkillsCommunication SkillsLeadership SkillsOrganizational Skills

Industry Keywords

AI StrategyPortfolio SequencingInvestment TrackingGovernance StandardsCompliance ConceptsMatrixed OrganizationStrategic InitiativesValue RealizationRisk ReportingInternational Travel

Tech Stack

Tools & technologies

Spark

About the role

Key responsibilities & impact

Own PMO management and portfolio sequencing across the AI Strategy & Realization team
Lead prioritization and intake of projects and programs based on strategic initiatives and value
Establish a consistent, transparent process for evaluating and sequencing new and in-flight work
Partner with the PGS Data, Analytics & AI Transformation portfolio team and Spark team on intake, value realization, and inventory standards
Manage financial tracking for the portfolio, including investment and spend
Capture, track, and hold pillar teams accountable for value realization
Partner with the PGS and Digital Responsible AI team on compliance and governance standards, including AIRIF, DPAL, and ITRM
Maintain a current inventory of AI Strategy & Realization initiatives
Provide leadership-ready reporting on status, risk, and resourcing
Identify capacity constraints and competing priorities and escalate trade-off decisions

Requirements

What you’ll need

Bachelor's degree in Business, Information Systems, Computer Science, or a related field with at least 6 or more years of experience; OR a master's degree with at least 5 years of experience, OR a PhD with at least 1 year of experience
Demonstrated experience running a PMO, portfolio management function, or project intake process within a large, matrixed organization
Working knowledge of prioritization and value realization frameworks
Experience with financial tracking and reporting for a multi-project or multi-program portfolio
Ability to partner with adjacent portfolio, governance, and compliance teams
Familiarity with AI/analytics governance and compliance concepts, including AIRIF, DPAL, and ITRM
Excellent organizational, analytical, and communication skills
Ability to travel domestically and internationally up to 10% of the year
Willingness to work off-hours to accommodate global time zones
Willingness to work extended or non-standard hours during peak periods
Candidates must be authorized to be employed in the U.S. by any employer
Permanent work authorization in the United States is required
U.S. work visa sponsorship is not available now or in the future

Benefits

Comp & perks

Global Performance Plan with a bonus target of 17.5% of base salary
Share based long term incentive program
401(k) plan with Pfizer Matching Contributions
Additional Pfizer Retirement Savings Contribution
Paid vacation, holiday and personal days
Paid caregiver/parental and medical leave
Medical, prescription drug, dental and vision coverage
Relocation assistance may be available based on business needs and/or eligibility