Senior Manager, Global Commercial Strategy – Early GI, Rheumatology, Neurology

Pfizer

. Support long-range commercial and portfolio strategy across Rheumatology, GI, and Neurology disease areas .

Posted 10/5/2026full-timeUnited StatesSenior💰 $124,400 - $207,400 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in commercial strategy development, portfolio management, and market access dynamics within the pharmaceutical and biotechnology sectors. Proficient in synthesizing complex scientific and market information to inform decision-making and drive strategic initiatives.

Highest-signal resume keywords

Commercial DevelopmentPortfolio StrategyMarket Access DynamicsCross-Functional Team LeadershipStrategic Analytical Skills

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Commercial Strategy DevelopmentPortfolio ManagementMarket ResearchForecastingValuationOpportunity AssessmentBusiness DevelopmentEvidence GenerationInvestment PrioritizationAI Tools Utilization

Soft Skills

Strong CommunicationExecutive PresenceProblem-SolvingStakeholder ManagementInfluencing Without Authority

Tools & Technologies

AI-Enabled ToolsDecision Support Systems

Industry Keywords

PharmaceuticalBiotechnologyLife SciencesRheumatologyGINeurologySpecialty CareComplex Therapeutic AreasMarket AccessPayer Considerations

About the role

Key responsibilities & impact

Support long-range commercial and portfolio strategy across Rheumatology, GI, and Neurology disease areas
Generate near-, mid-, and long-term views of disease-area opportunities, risks, and investment priorities
Synthesize scientific, clinical, commercial, access, competitive, and patient insights
Monitor scientific and competitive landscape shifts and identify emerging trends and implications
Translate disease-area strategy into recommendations and decision materials for leadership and governance forums
Provide commercial leadership for portfolio prioritization, investment choices, and development opportunities
Pressure-test commercial assumptions, value drivers, risks, uncertainties, and evidence needs
Lead executive-ready materials communicating strategic rationale, opportunity attractiveness, trade-offs, and recommended actions
Partner with cross-functional leaders on indication sequencing, evidence generation, market development, and lifecycle opportunities
Lead early commercial assessments for pipeline assets, mechanisms, indications, disease-area opportunities, and future product concepts
Develop product concepts, target product profiles, positioning hypotheses, market archetypes, commercial opportunity assessments, and forecast assumptions
Provide commercial input to clinical development, evidence generation, lifecycle, and indication sequencing discussions
Lead commercial strategy input for external innovation and Business Development opportunities
Assess strategic fit, market potential, valuation inputs, competitive scenarios, and portfolio implications
Influence cross-functional stakeholders and build relationships across R&D, Medical Affairs, GASP, BAI, Competitive Intelligence, Business Development, and Commercial Regions
Set expectations for responsible AI-enabled ways of working and champion AI-enabled tools for landscape synthesis, market insights, scenario development, and decision support
Continuously improve AI-enabled workflows, templates, portfolio reviews, and strategic decision-support processes

Requirements

What you’ll need

Bachelor's degree required; MBA or advanced degree preferred
6+ years with a BA/BS, 5+ years with MBA/MS, or 1+ years with PhD or JD of experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, corporate strategy, business development, market research, forecasting, analytics, or related field
Strong strategic and analytical skills
Ability to synthesize complex scientific, clinical, market, access, and competitive information into clear recommendations
Experience leading early commercial assessment, business case development, opportunity assessment, or cross-functional strategic planning
Ability to engage in scientific and clinical dialogue and translate implications for commercial opportunity, differentiation, portfolio value, and enterprise decision-making
Strong communication, executive presence, problem-solving, and stakeholder management skills
Experience in Rheumatology, GI, Neurology, I&I, specialty care, or other complex therapeutic areas preferred
Experience with commercial development, early asset strategy, portfolio management, Business Development assessments, forecasting, valuation, or investment prioritization
Demonstrated ability to develop long-term strategies and secure alignment from senior leadership
Understanding of market access dynamics, payer considerations, evidence generation, value demonstration, and lifecycle value optimization
Track record of leading cross-functional teams and influencing without authority
Comfort working in an AI-native or AI-augmented environment; experience using AI tools is a plus
Ability to thrive in ambiguity and adapt to evolving portfolio priorities
Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters
Ability to influence and collaborate with peers, develop and coach others, and oversee and guide colleagues
Candidates must be authorized to be employed in the U.S. by any employer
U.S. work visa sponsorship is not available now or in the future
Position requires permanent work authorization in the United States

Benefits

Comp & perks

Global Performance Plan bonus target of 17.5% of base salary
Eligibility to participate in Pfizer’s share based long term incentive program
401(k) plan with Pfizer Matching Contributions
Additional Pfizer Retirement Savings Contribution
Paid vacation, holiday and personal days
Paid caregiver/parental and medical leave
Medical, prescription drug, dental and vision coverage
Relocation assistance may be available based on business needs and/or eligibility