Senior Manager – Response Threat Operations

Pfizer

. Lead the AMER Response Threat Operations team, providing strategic direction, operational oversight, and people leadership .

Posted 11/11/2026full-timeUnited StatesSenior💰 $139,100 - $231,900 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in cybersecurity leadership, incident response, and threat detection, with a strong focus on operational excellence and team development. Proficient in utilizing advanced security tools and methodologies to manage and mitigate security threats effectively.

Highest-signal resume keywords

Cybersecurity LeadershipIncident Response MethodologiesThreat Detection and AnalysisAgile Project ManagementAdvanced Networking Knowledge

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

TCP/IPNetwork Threat Life CycleWindows Operating SystemComputer ProgrammingScripting LanguagesSecurity Analysis ToolsMalware AnalysisDigital ForensicsIncident ResponseProcess Optimization

Soft Skills

Leadership SkillsProblem-SolvingCommunication SkillsOrganizational AbilitiesCollaboration

Tools & Technologies

WiresharkSNORTSplunkKali LinuxSiftREMnux

Industry Keywords

Cyber DefenseThreat OperationsIncident ResponseSecurity ThreatsAgile Principles

Tech Stack

Tools & technologies

Cyber SecurityJavaLinuxPythonSplunkTCP/IP

About the role

Key responsibilities & impact

Lead the AMER Response Threat Operations team, providing strategic direction, operational oversight, and people leadership
Foster a high-performing, collaborative, and growth-oriented culture
Partner with Cyber Defense and CISO leadership to define and execute the long-term vision, strategy, and operational roadmap for threat detection, incident response, and cyber defense capabilities
Oversee 24x7 threat monitoring, incident response, and cyber intrusion analysis across global regions
Ensure effective identification, investigation, containment, and remediation of security threats
Drive operational excellence through process optimization, automation, metrics-driven decision making, and continuous improvement
Lead talent development through performance management, coaching, mentoring, workforce planning, hiring, and career development
Serve as a key stakeholder and regional representative for Threat Operations, partnering with business, technology, and security leaders to manage risk and communicate security impacts
Direct strategic programs and projects using Agile principles, ensuring efficient resource management, timely delivery, and measurable business outcomes
Provide technical leadership on cyber threat detection, digital forensics, malware analysis, threat intelligence, and incident response methodologies
Develop security incident response actions and monitor effectiveness metrics
Standard work schedule with occasional travel required (10–20%)

Requirements

What you’ll need

Bachelor's degree with 6+ years of experience, Master's degree with 5+ years of experience, or PhD with 1+ years of experience in cybersecurity, information security, computer science, or a related field
Advanced level understanding of TCP/IP, common networking ports and protocols, traffic flow, system administration, OSI model, defense-in-depth, and common security elements
Advanced level understanding of the life cycle of network threats, attacks, attack vectors and methods of exploitation, including intrusion set tactics, techniques, and procedures (TTPs)
Advanced level knowledge of the Windows operating system, system utilities, and admin functions
Significant experience with open-source security analysis tools such as Wireshark, SNORT, Splunk, Kali Linux, Sift, and REMnux
Experience with computer programming and scripting languages such as C, Python, and Java
Ability to proactively solve complex problems individually and as part of a team
Leadership skills with the ability to prioritize and execute with minimal direction or oversight
Outstanding written and verbal communication skills, including articulating industry terminology at technical, management, and senior executive levels
Organizational, planning, and administrative abilities, with the ability to coordinate multiple complex projects simultaneously
Demonstrated experience in an agile work environment, with a collaborative mindset, adaptability to change, and proactive problem-solving approach
Permanent work authorization in the United States

Benefits

Comp & perks

Pfizer Global Performance Plan with a bonus target of 17.5% of base salary
Share based long term incentive program
401(k) plan with Pfizer Matching Contributions
Additional Pfizer Retirement Savings Contribution
Paid vacation, holiday and personal days
Paid caregiver/parental and medical leave
Medical, prescription drug, dental and vision coverage
Relocation assistance may be available based on business needs and/or eligibility