Vice President, Applied AI & Architecture

Pfizer

. Define and evolve the applied AI strategy supporting CMO and Commercial priorities .

Posted 10/8/2026full-timeUnited StatesLead💰 $274,000 - $456,600 per yearWebsite

Core Competencies

Role fit

Core Competencies

Use this summary to align your resume positioning with the role.

Demonstrates extensive expertise in applied AI and enterprise architecture, with a strong focus on defining AI strategies, target architectures, and governance frameworks. Proven ability to lead cross-functional teams and influence stakeholders in complex, regulated environments.

Highest-signal resume keywords

Applied AI ExpertiseEnterprise ArchitectureTechnical LeadershipAI Strategy DevelopmentRegulatory Compliance

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Artificial IntelligenceMachine LearningData IntegrationArchitecture StandardsGenerative AIAgentic SystemsModel EvaluationAI ObservabilityCloud PlatformsSoftware Engineering

Soft Skills

Influencing ExecutivesCross-Functional CollaborationCommunication SkillsLeadership PresenceTeam Building

Certifications & Qualifications

Bachelor’s Degree in Computer ScienceAdvanced Degree in Relevant Discipline

Industry Keywords

PharmaceuticalsHealthcareLife SciencesRegulated IndustryAI-Enabled WorkflowsHuman-Agent Operating ModelsAI Technologies EvaluationTechnical Decision FrameworksGovernance FrameworksTransformation Programs

Tech Stack

Tools & technologies

CloudCyber Security

About the role

Key responsibilities & impact

Define and evolve the applied AI strategy supporting CMO and Commercial priorities
Translate business and transformation ambitions into technical direction and capability roadmaps
Define the target architecture connecting AI capabilities, commercial data, enterprise platforms, applications, workflows, and user experiences
Establish scalable, secure, reusable, and interoperable AI architecture patterns
Provide senior applied AI and architecture leadership for AI evolution workstreams
Shape AI architecture for internal process transformation and broader Commercial Transformation priorities
Create frameworks for evaluating AI use cases, technologies, models, vendors, platforms, and architectural approaches
Establish standards for AI solution architecture, agent design, model selection, retrieval, evaluation, observability, interoperability, and human oversight
Drive reuse of common AI capabilities, services, components, and patterns across the portfolio
Conduct architecture and technical-design reviews for significant AI initiatives
Challenge assumptions and validate technical feasibility, scalability, responsibility, and enterprise alignment
Partner with transformation, product, data, Digital, engineering, governance, and risk-management leaders
Embed responsible AI, privacy, security, regulatory, legal, compliance, and quality considerations into solution architecture
Build and lead a team of senior applied AI architects, solution architects, principal engineers, and technical experts
Establish career pathways and communities of practice for applied AI and architecture talent
Serve as a trusted technical adviser to CMO, Commercial, AIA, and Digital leaders
Represent applied AI architecture in technology, investment, transformation, and governance forums
Communicate technical vision, business implications, and recommendations to executive stakeholders

Requirements

What you’ll need

15+ years of progressive experience in artificial intelligence, machine learning, data, enterprise architecture, software engineering, or technology strategy, or equivalent based on advanced degree
Significant senior leadership experience shaping technical direction across a large, complex, and matrixed organization
Deep expertise in applied AI, including generative AI, agentic systems, machine learning, retrieval architectures, evaluation, observability, and enterprise integration
Proven experience defining enterprise or domain-level AI strategies and target architectures
Demonstrated success translating complex business transformation priorities into technical strategies, roadmaps, and solution designs
Experience establishing architecture standards, technical decision frameworks, and governance across multiple teams or business domains
Strong understanding of enterprise data, cloud, platform, application, integration, cybersecurity, and software-engineering considerations
Experience influencing senior executives and technical leaders without relying solely on direct organizational authority
Demonstrated success working across product, transformation, business, data, architecture, and engineering organizations
Experience operating in a highly regulated and complex enterprise environment
Bachelor’s degree in computer science, engineering, mathematics, data science, or another relevant technical or quantitative discipline, or equivalent professional experience
Advanced degree in a relevant discipline preferred
Experience in pharmaceuticals, healthcare, life sciences, or another highly regulated industry preferred
Experience defining architecture for AI-enabled commercial platforms or enterprise transformation programs preferred
Direct experience with large language models, agent orchestration, retrieval-augmented generation, model and agent evaluation, and AI observability preferred
Experience developing human-agent operating models and architecture for AI-enabled workflows preferred
Demonstrated success building applied AI architecture capabilities or technical centers of excellence preferred
Experience evaluating emerging AI technologies, strategic vendors, and external partnerships preferred
Recognized internal or external leadership presence in applied AI, enterprise architecture, or AI-enabled transformation preferred
Ability to work across global teams and time zones
Candidates must be authorized to be employed in the U.S. by any employer
Permanent work authorization in the United States is required
U.S. work visa sponsorship is not available now or in the future

Benefits

Comp & perks

Global Performance Plan with a bonus target of 30.0% of base salary
Share-based long-term incentive program
401(k) plan with Pfizer Matching Contributions
Additional Pfizer Retirement Savings Contribution
Paid vacation, holiday, and personal days
Paid caregiver/parental and medical leave
Medical, prescription drug, dental, and vision coverage
Relocation assistance may be available based on business needs and/or eligibility