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Sanofi

Principal Scientist, Quantitative Systems Pharmacology

Sanofi

. Develop and apply multiscale computational models of complex diseases based on detailed biological mechanistic knowledge .

Posted 10/12/2026full-timeUnited StatesLead💰 $122,250 - $176,583 per yearWebsite

Core Competencies

Role fit
Core Competencies

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Demonstrates expertise in developing multiscale computational models for complex diseases, with a strong foundation in mathematical modeling and proficiency in computational tools like MATLAB, Julia, and R. Capable of effectively communicating modeling predictions and collaborating within multidisciplinary teams.

Highest-signal resume keywords
PhD Or Master's Degree In Systems PharmacologyMathematical Modeling Using Differential EquationsMachine Learning ExperienceComputational Tools: MATLAB, Julia, RKnowledge Of Immuno-Oncology Or Neuroscience

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills
Multiscale Computational ModelingDisease Model GenerationMechanistic/Multiscale ModelsQuantitative Systems PharmacologyData AnalysisSimulation Result AnalysisModel Performance ResolutionDocumentation MaintenancePharmacometric ExperiencePathophysiology Learning
Soft Skills
Excellent Oral CommunicationExcellent Written CommunicationDetail-OrientedHighly MotivatedIndependent ResearcherCollaborative Teamwork
Industry Keywords
Drug DiscoveryDrug DevelopmentPharmaceutical IndustryPreclinical Data AnalysisClinical Data Analysis

About the role

Key responsibilities & impact
  • Develop and apply multiscale computational models of complex diseases based on detailed biological mechanistic knowledge
  • Support model-informed drug discovery and development across the R&D portfolio
  • Survey literature to understand critical physiological processes and identify suitable mechanistic elements, data, parameters and assumptions
  • Identify and analyze suitable preclinical and clinical data to inform modeling activities
  • Analyze simulation results and develop strategies to resolve model performance and accuracy issues
  • Maintain extensive documentation of model development and data analysis
  • Maintain quantitative systems pharmacology expertise through comprehensive education
  • Communicate modeling predictions to key stakeholders

Requirements

What you’ll need
  • PhD or Master's degree in systems pharmacology, biology, computational biology, systems biology, biomedical engineering, or a related field
  • For candidates with PhD degrees: Minimum 2 years of hands-on experience generating disease models, mechanistic/multiscale models or QSP models
  • For candidates with Master degrees: Minimum 4 years of experience generating disease models, mechanistic/multiscale models or QSP models in industry/pharma setting
  • Proficiency in mathematical modeling using differential equations
  • Machine learning experience
  • Extensive experience in computational tools such as MATLAB, Julia and R (MATLAB preferred)
  • Excellent oral and written communication skills
  • Ability to quickly learn pathophysiology in indications of interest
  • Highly motivated, detail-oriented, and independent researcher
  • Able to thrive in a collaborative, multi-disciplinary team environment
  • Strong commitment to on-the-job-training
  • Knowledge of Immuno-oncology or Neuroscience
  • Record of increasing responsibility and independence, developing and applying QSP approaches
  • Experience in drug discovery/development a plus, especially in pharmacometrics

Benefits

Comp & perks
  • Employees may be eligible to participate in Company employee benefit programs
  • Development opportunities designed to match your ambition
  • Stretch roles and cross-functional moves
  • Inclusive, high-performing teams
  • On-the-job training