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Tempus AI

Senior Scientist II, Computational Biology

Tempus AI

. Partner with pharmaceutical collaborators on target discovery, biomarker development, and clinical development .

Posted 9/30/2026full-timeUnited StatesSenior💰 $100,000 - $175,000 per yearWebsite

Core Competencies

Role fit
Core Competencies

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Demonstrates expertise in Computational Biology, Bioinformatics, and Machine Learning, with a strong focus on integrating genomic and clinical data for innovative insights. Proficient in R and Python, with a solid understanding of cancer biology and the drug development lifecycle.

Highest-signal resume keywords
PhD In Computational BiologyProficiency In R And PythonMachine Learning ApplicationProject Leadership And MentorshipExperience Analyzing Large-Scale Biological Datasets

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills
Computational BiologyBioinformaticsMachine LearningStatistical AnalysisData AnalysisCode ReviewQuality AssuranceSurvival AnalysisCausal InferenceNetwork Biology
Soft Skills
Excellent Communication SkillsMentorshipCollaboration
Tools & Technologies
Tempus Multimodal PlatformLLMsSQLVersion ControlScientific Computing Libraries
Industry Keywords
Clinical DevelopmentBiomarker DevelopmentDrug Development LifecycleReal-World EvidenceNGSRNA-seqTranscriptomics

Tech Stack

Tools & technologies
PythonSQL

About the role

Key responsibilities & impact
  • Partner with pharmaceutical collaborators on target discovery, biomarker development, and clinical development
  • Translate partner needs into key questions, technical requirements, and analytical plans using the Tempus multimodal platform
  • Execute reproducible analyses integrating genomic, transcriptomic, imaging, and clinical data
  • Generate insights for clinical trial design, patient selection, treatment response, resistance mechanisms, and disease biology
  • Incorporate LLMs and AI tools to automate and accelerate coding, discovery, documentation, and review
  • Design and prototype agentic workflows using foundation models and LLMs for new insights and predictive models
  • Evaluate, adapt, and implement methods for real-world, clinical, and omic datasets
  • Contribute reusable code, internal packages, and analytical best practices
  • Collaborate with Research, Clinical, Data Science, and Engineering teams on scalable solutions and platform/product roadmaps
  • Communicate methods and results to technical and non-technical stakeholders
  • Prepare internal reports, external deliverables, manuscripts, and conference materials
  • Lead projects, set priorities, coordinate resources, address obstacles, mentor junior scientists, and ensure milestones are met

Requirements

What you’ll need
  • PhD in Computational Biology, Bioinformatics, Biostatistics, Machine Learning, or a related field, or a Master's degree with 4+ years of relevant experience
  • Plus an additional 2+ years of relevant industry or post-doctoral experience
  • Proven track record in peer-reviewed publications
  • Proficiency in R and/or Python, including common computational biology and scientific computing libraries
  • Proficiency applying machine learning, LLM-based coding assistants, and agentic frameworks for biological/clinical research
  • Good software engineering practices, including version control, modular code, and documentation
  • Strong grounding in statistics and data analysis, including study design and interpretation of real-world clinical data
  • Proficiency in code review and QA/QC
  • Strong understanding of cancer biology, immunology, or human disease mechanisms
  • Experience analyzing large-scale biological datasets such as NGS, RNA-seq, genomics, or transcriptomics data
  • Demonstrated project leadership and people mentorship
  • Excellent written and verbal communication skills with comfort in client-facing roles
  • Practical experience configuring or adapting LLMs or related tools/frameworks
  • Expertise in RWE, survival analysis, causal inference, network/systems biology, or multi-modal integration
  • Understanding of the drug development lifecycle
  • Experience working with SQL and large relational databases

Benefits

Comp & perks
  • Incentive compensation
  • Restricted stock units
  • Medical benefits
  • Other benefits depending on the position