Principal Software Engineer – .NET, Azure

Thermo Fisher Scientific

. Design, build, and maintain large-scale distributed systems on Azure using .NET/C# .

Posted 10/22/2026full-timeRemoteLeadWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates extensive experience in designing and maintaining large-scale distributed systems on Azure using .NET/C#. Proven ability to engage with stakeholders, translate requirements into technical solutions, and drive architectural decisions while mentoring engineers and ensuring high-quality engineering practices.

Highest-signal resume keywords

C# Programming.NET FrameworkMicrosoft AzureCI/CD PipelinesBackend Services Ownership

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

C#.NET 6+ASP.NET CoreAzure FunctionsAzure SQLCosmos DBEntity Framework CoreSQL ServerMicroservices PatternsEvent-Driven Architectures

Soft Skills

Excellent CommunicationRelationship BuildingProblem SolvingMentoring

Tools & Technologies

Azure DevOpsBicepTerraformDockerApplication InsightsAzure Monitor

Industry Keywords

HealthcareLife SciencesFinanceRegulatory ComplianceHIPAAEHREMRHL7FHIR

Tech Stack

Tools & technologies

ASP.NETAzureCloudDistributed SystemsDockerEntity FrameworkMicroservicesSQLTerraformVault.NET

About the role

Key responsibilities & impact

Design, build, and maintain large-scale distributed systems on Azure using .NET/C#
Navigate and contribute to complex legacy and modern codebases with minimal ramp-up time
Engage directly with business stakeholders to build domain expertise and translate requirements into technical solutions
Drive architectural decisions, trade-off analyses, and technical strategy
Own backend services end-to-end, including APIs, data access, cloud infrastructure, and CI/CD pipelines
Mentor and unblock engineers while improving engineering quality and practices
Collaborate across organizational boundaries to align technical work with business outcomes
Identify and resolve systemic issues in production environments, tooling, and development workflows

Requirements

What you’ll need

10+ years of professional software engineering experience
Strong proficiency in C# and .NET, including .NET 6+ / ASP.NET Core
Deep experience with Microsoft Azure, including App Services, Azure Functions, Service Bus, Azure SQL, Cosmos DB, Storage, Key Vault, and Entra ID
Ability to operate independently in ambiguous, complex environments with large codebases and distributed systems
Track record of shipping and maintaining production backend systems at scale
Experience in regulated or domain-heavy industries such as healthcare, life sciences, or finance
Excellent communication skills and ability to build relationships with non-technical stakeholders
Ability to translate between business and engineering contexts
End-to-end ownership from requirements gathering through deployment and operational support
Preferred: Health & Life Sciences technology experience, including EHR/EMR, clinical data, regulatory compliance, HIPAA, or HL7/FHIR
Preferred: Azure DevOps, CI/CD pipelines, and Infrastructure as Code using Bicep or Terraform
Preferred: Event-driven architectures, microservices patterns, and distributed messaging
Preferred: Data-intensive systems, pipelines, or ML/AI integrations in healthcare
Preferred: Leading cross-team initiatives or serving as a technical anchor
Experience with .NET 8+, ASP.NET Core Web APIs, Azure Functions, Worker Services, AKS/Containers, Event Grid, Blob Storage, MSAL, SQL Server, Entity Framework Core, Git, Docker, Application Insights, and Azure Monitor

Benefits

Comp & perks

Contractor-only engagement
Global remote work arrangement