Centessa Pharmaceuticals

Director

• Lead the medicinal chemistry component of a multidisciplinary CNS GPCR drug discovery program
• Guide a geographically distributed organization including internal chemistry staff, CRO-based synthetic chemistry teams, consultants, and partners
• Lead and manage internal chemistry resources and outsourced chemistry teams
• Set priorities, resolve synthetic challenges, and direct groups toward IND-ready candidate molecules
• Serve as chemistry leader within the broader multidisciplinary project team
• Build working relationships with colleagues, partners, consultants, and CROs
• Design new molecules addressing the target product profile and establish intellectual property
• Develop chemistry strategies supporting a robust intellectual property position
• Analyze SAR from weekly pharmacology and ADME data to identify opportunities for improved molecules
• Maintain awareness of competitor activities and medicinal chemistry developments
• Maximize throughput of test compounds
• Utilize structure-based drug design knowledge and compound-property computational predictive tools
• Present data and articulate next steps at chemistry-focused and cross-functional meetings
• Defend proposed designs using SAR and literature precedent
• Communicate ideas clearly in writing and verbally with project teams and senior management

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Director, Medicinal Chemistry