Deep Origin

Principal

• Lead and advance small molecule drug discovery programs from early hit identification through IND-enabling studies
• Direct work completed at contract research organizations (CROs)
• Propose and independently drive medicinal chemistry strategies from hit identification through lead optimization to development candidate selection
• Lead chemistry efforts within cross-functional teams including bench biologists, DMPK, non-clinical toxicology, computational science, and ML engineering
• Design, prioritize, and guide synthesis of novel compounds using structure-based and ligand-based approaches
• Optimize potency, selectivity, pharmacokinetics, and developability
• Interpret and integrate SAR, structural biology, DMPK, pharmacology, and safety data
• Integrate AI-driven and computational modeling insights into compound design strategies
• Mentor internal chemists and external collaborators
• Manage external CRO partnerships for high-quality and timely chemistry delivery
• Communicate program strategy, data, risks, and recommendations to senior leadership
• Author and contribute to patent strategies and applications, scientific publications, and internal reports

Explore Principal – AD Medicinal Chemist at Deep Origin. Review requirements and application details.