Substrate

Software Engineer

• Own the analysis of functional genomics data
• Act as the main computational partner to scientists running perturbation screens
• Contribute from screen design through hit selection and evidence presentation
• Analyse multimodal data from single-cell and pooled CRISPR screens, sequencing, Cell Painting, high-content imaging and proteomics
• Review existing analysis and QC for CRISPR screens and Cell Painting
• Perform QC, guide assignment, differential expression and modelling of perturbation effects
• Build an image-based Cell Painting profiling pipeline covering feature extraction, normalisation and phenotypic scoring
• Advise on screen design, including power, replication, library coverage, plate layout and batch effects
• Integrate proteomic, transcriptomic and imaging readouts from the same perturbations
• Build reproducible and versioned pipelines with the software team
• Present results, uncertainty and QC to scientists and leadership
• Work closely with functional genomics scientists and the software team
• Report into the intelligence team

Explore Member of Technical Staff – Intelligence, Functional Genomics at Substrate. Review requirements and application details.