Sanford Burnham Prebys

Technician

• Care for laboratory research mice and rats under supervision of the Animal Facility Manager and, at times, the Lead Husbandry Technician
• Check cages daily for adequate food and water and replenish supplies
• Change cages on the 10-day cage change cycle
• Check and correct cage card information
• Maintain animal room activity logs and husbandry records
• Maintain changing hoods, ventilated animal housing racks, and related equipment
• Perform daily animal health checks and report conditions to Laboratory Animal Technicians
• Restock room supplies and maintain storage and procedure support areas
• Clean and maintain animal rooms, support areas, and procedure labs
• Perform routine animal health treatments, blood collection, and injections as assigned
• Cross-train with LAT staff and perform breeding colony maintenance, including weaning litters and ear notching mice
• Assist with cage washroom duties
• Wash rodent cages and accessories and operate tunnel and rack washers
• Organize cleaned caging and prepare it for autoclaving
• Operate the steam autoclave and bedding dispenser
• Add nesting material to bedding-filled cages
• Prepare and label cleaning solutions
• Perform rodent euthanasia
• Clean and restock procedure rooms
• Perform other assigned related duties

Husbandry Technician II

• Maintain research laboratory mouse breeding colonies for multiple PIs/labs under direct supervision of the Breeding Colony Manager
• Perform breeding colony maintenance for approximately 500–800 cages, including cage changing
• Change cages according to AF Husbandry SOPs
• Perform husbandry for immunocompromised mice and in viral vector BSL-2, quarantine, infectious containment, and Specific Pathogen Free areas as assigned
• Complete daily animal health checks, including food and water checks and observations for illness, injury, distress, pregnancies, and new litters
• Complete and distribute health status forms to labs
• Perform mating, timed mating with vaginal sperm plug checks, litter weaning, ear notching, and tail snip collection for genotyping
• Maintain accurate breeding colony records in LabTracks
• Communicate with research PIs and lab contacts regarding colony requests, production, non-productive breeders, sick animals, and deceased animals
• Update researchers on breeding colony workflow status
• Report health concerns to the Attending Veterinarian, Manager, Animal Health Coordinator, and research PI/lab contact
• Determine animal-welfare actions, including euthanasia, when direct orders are unavailable
• Treat routine conditions such as dermatitis and abrasions; separate aggressive animals and provide enrichment
• Read Animal Use Protocols, document special care requirements, and maintain animal and cage census records
• Perform authorized technical animal procedures, including blood collection, IV/IP/IM/SC injections, and oral dosing
• Assist with cross-training LAT I staff
• Perform other related duties as assigned

Lab Animal Technician II

Associate

• Conduct research using hiPSC to model neurological disease
• Develop patient-specific, cell-based models for neurological disease
• Screen for drugs and validate new targets and chemical molecules
• Investigate underlying cellular and molecular processes
• Develop neurological disease phenotype models using patient-specific iPSCs
• Use high-throughput drug screening technologies
• Generate hypotheses and design experiments
• Interpret data, troubleshoot, and optimize experiments
• Analyze data from different sources and draw relevant conclusions
• Present results at internal and external meetings
• Accurately document experiments
• Contribute to reports and manuscripts with increasing responsibility
• Collaborate across lab functions and train junior lab staff as needed
• Perform other related duties as assigned

Postdoctoral Associate

Full-stack Engineer

• Provide technical leadership for software engineering applied to complex biomedical data
• Architect and implement sophisticated, modular, multi-language software for very large datasets
• Support SDLC, Dev/Ops, data ingestion, quality control, feature extraction, data visualization, scalable analyses, parallelization, concurrency, full-stack interfaces, containerization, and load-sensitive design
• Design and implement software solutions across programming languages and computing environments
• Improve code quality and productivity for large, mixed-skill development teams
• Collaborate with bioinformaticians, cloud operations, and related teams
• Provide technical guidance and mentorship to junior staff, software engineers, and trainees
• Identify technical opportunities, algorithms, and software development opportunities
• Participate in funding applications and external collaborations with research groups, commercial entities, and partner organizations
• Provide technical support and computer science/software engineering expertise across the organization
• Generate peer-reviewed scientific research as lead and collaborator
• Contribute to open-source software development
• Set project milestones with the PI and manage technical staff to meet them
• Establish software-development infrastructure for the Institute cancer data science group
• Architect, design, and implement robust software development practices
• Develop cancer data science software in C++, Python, Perl, R, and other languages
• Optimize software for high-performance computing environments using containerization, Dev/Ops, test-driven development, and cloud-engineering techniques
• Assist with systems administration in coordination with Dev/Ops, Sys/Ops, and Cloud/Ops
• Write user-facing and developer-facing documentation
• Implement and optimize AI-based software development tools
• Present project results and ideas verbally and in writing
• Perform other related duties as assigned

Principal Software Engineer

• Join the Feng Laboratory at Sanford Burnham Prebys Medical Discovery Institute
• Use cryo-electron microscopy to determine high-resolution structures of membrane proteins and protein complexes
• Apply biochemical and biophysical approaches to investigate protein function and elucidate structure–function relationships
• Generate hypotheses and design experiments
• Interpret data, troubleshoot, and optimize experiments
• Analyze data from different sources and draw relevant conclusions
• Present results at internal and external meetings
• Accurately document experiments
• Contribute to writing reports and manuscripts with increasing responsibility
• Collaborate across lab functions
• Train junior lab staff as needed
• Provide mentorship to interns and lab members
• Work on structural and functional mechanisms of disease-related membrane proteins and endogenous ion channels

• Perform basic molecular techniques including cloning, DNA and protein work
• Perform real-time PCR, cell-based cDNA transfections, virus packaging, protein expression and purification, and maintenance of mammalian cell lines
• Contribute to diverse laboratory procedures, practices, and protocols under specific direction
• Oversee equipment installation and maintenance
• Order and stock laboratory supplies
• Maintain reagent collections and inventories
• Train and mentor new laboratory personnel
• Perform experiments determined by the Principal Investigator and postdoctoral researchers
• Keep written records of experiments and organize data
• Provide data interpretation and initial analysis of results
• Operate specialized equipment and troubleshoot problems
• Work on structural and functional mechanisms of disease-related membrane proteins and protein complexes, with a focus on ion channels

Husbandry Technician II

Lab Animal Technician II

Postdoctoral Associate

Principal Software Engineer

Postdoctoral Associate

Scientific Associate