Demonstrates expertise in synthetic chemistry, including route optimization and scale-up, while effectively collaborating with cross-functional teams and leveraging AI-powered tools for drug discovery. Proven ability to mentor and train laboratory technicians to ensure safe and reproducible execution of reactions.

Highest-signal resume keywords

Synthetic Chemistry ExpertiseRoute OptimizationCRO ManagementMentoring Junior ChemistsAI-Powered Drug Discovery Tools

About the role

Key responsibilities & impact

Design, optimize, and troubleshoot synthetic routes across diverse medicinal chemistry programs
Translate practical chemistry knowledge into digital workflows for route optimization, reaction-condition identification, CRO communication, and compound tracking
Oversee synthesis activities with CRO partners to deliver high-quality compounds efficiently
Train and mentor laboratory technicians to execute reactions safely, effectively, and reproducibly
Develop strategic approaches to compound and intermediate supply, including route optimization and scale-up
Collaborate with medicinal chemists, computational scientists, and engineers
Integrate hands-on chemistry expertise with AI-powered drug discovery tools and workflows
Report directly to the VP, Head of Medicinal Chemistry

Requirements

What you’ll need

Passion for advancing medicinal chemistry programs through practical, hands-on synthetic chemistry
Deep knowledge of modern synthetic methods and practical bench chemistry
Track record of solving complex synthetic challenges across diverse chemotypes, reaction types, and scales
Experience mentoring junior chemists or technicians
Strong communication and collaboration skills
Demonstrated experience managing synthesis CROs, including FTE-based teams and fee-for-service projects across multiple partners
Strategic thinking around material supply, route optimization, key intermediate development, and scale-up
Curiosity about emerging technologies and interest in applying AI agents and digital tools to synthesis workflows
Experience overseeing scale-up synthesis for in vivo toxicology studies or other late-stage drug discovery activities (bonus)
Experience applying AI, automation, or digital tools to synthetic chemistry workflows (bonus)
Experience at the intersection of medicinal chemistry, computational chemistry, and experimental drug discovery (bonus)
Ability to work onsite in Boston with regular visits to the local lab
Visa transfer or sponsorship requirements may apply, as addressed in the application form

Benefits

Comp & perks

Equity-based compensation
Comprehensive healthcare benefits
Dental insurance
Vision insurance
Opportunity to grow with a rapidly scaling company
Full lives beyond their career

ATS Keywords

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Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills

Modern Synthetic MethodsPractical Bench ChemistryComplex Synthetic Problem SolvingScale-Up SynthesisIntermediate Development

Soft Skills

Strong Communication SkillsCollaboration SkillsStrategic Thinking

Tools & Technologies

AI AgentsDigital WorkflowsAutomation Tools

Industry Keywords

Medicinal ChemistryComputational ChemistryDrug DiscoveryCRO CommunicationIn Vivo Toxicology Studies