Senior Director, Portfolio Strategy – Global Commercial Strategy, Oncology
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Posted: 10/20/2026
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Role fitCore Competencies
Use this summary to align your resume positioning with the role.
Demonstrates expertise in portfolio strategy development, capital allocation, and decision-making within the oncology landscape, leveraging strong analytical and strategic skills to influence senior leadership and drive cross-functional initiatives.
Highest-signal resume keywords
Portfolio Strategy DevelopmentOncology ExperienceCross-Functional LeadershipStrategic Decision-MakingAI-Enabled Tools Utilization
About the role
Key responsibilities & impact- Lead development and evolution of Pfizer Oncology portfolio strategy across tumor types, mechanisms, modalities, and therapeutic platforms
- Develop long-range portfolio scenarios and strategic roadmaps to inform investment priorities and portfolio evolution
- Assess portfolio strengths, gaps, risks, and opportunities to support decision-making and resource allocation
- Drive portfolio-level strategic trade-off discussions balancing scientific opportunity, probability of success, patient impact, and commercial value
- Translate scientific and market dynamics into actionable portfolio recommendations for senior leadership
- Advise Oncology leadership on portfolio prioritization and capital allocation decisions
- Develop recommendations for governance committees and enterprise decision-making forums
- Establish frameworks improving consistency, rigor, and transparency in portfolio evaluations
- Drive discussions on investment prioritization, development sequencing, indication expansion, and lifecycle optimization
- Support portfolio assessments, valuations, critical portfolio reviews, and recommendation development
- Integrate scientific, clinical, epidemiologic, access, policy, patient, competitive, and commercial insights into portfolio strategies
- Monitor emerging oncology trends and evolving standards of care
- Evaluate disruptive technologies, novel modalities, and future treatment paradigms
- Develop strategic perspectives on the oncology landscape and implications for Pfizer
- Lead commercial dashboards, reports, and scenario planning for senior leadership
- Partner across Research, Development, Medical, Commercial, Access, Regulatory, Finance, and Business Development
- Lead highly visible, cross-functional strategic initiatives with enterprise-wide impact
- Advance portfolio management capabilities, methodologies, and AI-enabled decision-support approaches
- Serve as a strategic thought partner and influencer across the Oncology organization
- Mentor and develop colleagues and foster strategic thinking, innovation, and analytical rigor
- Lead and influence complex, matrixed cross-functional teams
- Support governance forums, portfolio reviews, strategy discussions, development decision points, and investment prioritization meetings
- Build trusted relationships across global, regional, and local stakeholders
- Provide senior leadership to integrate heme strategies across disease-area, asset, launch, access, and regional considerations
- Set priorities, accountabilities, and ways of working for high-quality strategic outputs
- Develop team capability in scientific and competitive landscape assessment, early commercial strategy, portfolio decision support, business case development, and executive communication
- Use AI-enabled tools for landscape synthesis, market insight generation, scenario development, portfolio analysis, and strategy efficiency
- Apply AI-augmented approaches to identify patterns across complex data sources and improve strategic outputs
- Champion responsible, compliant AI-enabled ways of working
- Build team capability in AI-enabled strategy development and commercial decision support
- Stay current on tools and practices supporting portfolio strategy, commercial development, and launch-readiness decisions
Requirements
What you’ll need- Bachelor's degree required
- 12+ years of successful, progressive experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, business development, strategy consulting, corporate strategy, or related fields
- Experience in Oncology
- Demonstrated experience leading enterprise-level strategic initiatives and influencing significant investment decisions
- Experience leading highly visible, cross-functional initiatives in complex matrix organizations
- Proven ability to synthesize scientific, clinical, commercial, competitive, and financial information to support portfolio prioritization and capital allocation decisions
- Strong strategic, analytical, and financial acumen, including experience evaluating risk, uncertainty, and value creation across multiple opportunities
- Track record of influencing senior leadership and driving alignment among diverse stakeholder groups
- Excellent communication, facilitation, organizational, and executive-ready storytelling skills
- Advanced degree in business, life sciences, medicine, pharmacy, public health, or related field preferred
- Experience developing long-range portfolio strategies covering multiple disease areas, modalities, or therapeutic platforms
- Experience supporting governance bodies, investment committees, or enterprise portfolio reviews
- Demonstrated success shaping portfolio prioritization frameworks, resource allocation decisions, and strategic trade-off discussions
- Experience assessing internal pipeline opportunities and external innovation opportunities, including licensing, partnerships, and acquisitions
- Deep understanding of portfolio management principles, valuation methodologies, forecasting, and investment decision-making
- Deep understanding of the oncology ecosystem, including evolving standards of care, emerging science, competitive dynamics, and future market evolution
- Experience evaluating opportunities across multiple tumor types and mechanisms
- Ability to connect scientific innovation with portfolio-level value creation and strategic differentiation
- Experience advising senior executives on complex strategic decisions with significant business impact
- Demonstrated ability to lead through ambiguity and navigate competing stakeholder priorities
- Experience establishing strategic frameworks, processes, or capabilities that improve organizational decision-making
- Comfort operating in an AI-enabled or AI-augmented environment; experience using AI tools for strategy, synthesis, scenario planning, or analysis is a plus
- Ability to make decisions and recommendations with incomplete information and lead teams through evolving portfolio priorities
- Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters
- Ability to influence and collaborate with peers, develop and coach others, and oversee and guide colleagues to achieve meaningful outcomes and business impact
- Candidates must be authorized to be employed in the U.S. by any employer
- Permanent work authorization in the United States required
- U.S. work visa sponsorship is not available now or in the future
Benefits
Comp & perks- Pfizer Global Performance Plan with a bonus target of 22.5% of base salary
- Share based long term incentive program
- 401(k) plan with Pfizer Matching Contributions
- Additional Pfizer Retirement Savings Contribution
- Paid vacation, holiday and personal days
- Paid caregiver/parental and medical leave
- Medical, prescription drug, dental and vision coverage
- Relocation assistance may be available based on business needs and/or eligibility
ATS Keywords
✓ Tailor your resumeApplicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard Skills
Portfolio Management PrinciplesValuation MethodologiesRisk EvaluationFinancial AcumenLong-Range Strategic PlanningMarket Insight GenerationScenario DevelopmentInvestment Decision-MakingCompetitive Landscape AssessmentTherapeutic Platforms Knowledge
Soft Skills
Excellent Communication SkillsFacilitation SkillsOrganizational SkillsExecutive StorytellingInfluencing Skills
Tools & Technologies
AI-Enabled ToolsMarket Analysis ToolsScenario Planning ToolsPortfolio Analysis Tools
Certifications & Qualifications
Bachelor's DegreeAdvanced Degree Preferred
Industry Keywords
PharmaceuticalBiotechnologyLife SciencesCommercial DevelopmentBusiness DevelopmentOncology EcosystemEmerging ScienceInvestment CommitteesGovernance BodiesTherapeutic Modalities